The Challenge of a Short Healthspan
While advancements in science have steadily increased lifespan, they haven’t extended healthspan, which is the period of life spent in good health. Ageing remains the biggest risk factor for poor health, leading to chronic conditions that affect the quality of life in later years.
We envision a future where people maintain independence, enjoy their favourite activities and spend quality time with loved ones well into their life.
Though many face declining vitality, recent scientific breakthroughs offer hope for ageing with energy, flexibility, and a continued sense of wellbeing.
The Hallmarks of Ageing
As we age, the structure, function and processes within our cells change. The scientific community widely recognises several key factors, known as the “Hallmarks of Ageing”:
Instability
Alterations
Attrition
Dysfunction
Communication
Exhaustion
Senescence
Nutrient Sensing
Proteostasis
Autophagy
Dysbiosis
These hallmarks manifest externally through changes in skin elasticity, hair colour and pigmentation, and internally through issues like poor sleep, declining energy, altered autophagy, NAD+ levels and telomere structure.
Tailored Support for Biological Age
At Elevate BleuTM, we recognise that support needs differ at various stages of biological age. Our premium products are designed to provide targeted support based on your unique biological age or lifestyle factors. Our formulations support the ageing process in ways previous generations did not have access to, offering personalised solutions to enhance healthspan and improve overall wellbeing.
Traditionally, there are eleven body systems:
System
System
System
System
System
System
System
System
System
System
System
In addition to these eleven systems, supporting your cellular health is the foundation for overall healthy ageing. By taking care of your cells, you support all eleven other body systems, promoting comprehensive wellbeing.
NAD水平
- NAD+ levels with precursor supplementation
- 自然NAD水平与年龄
nad+
年龄
NAD+ and its significance explained
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of the body that plays a crucial role in energy production and maintaining cellular health.[1] 辅酶是经过科学证明,以提高活动的所有七个去.[2] When NAD+ levels are high, sirtuins become more active, supporting cellular function.[3]
NAD+ helps convert nutrients into energy and is responsible for critical cell functions, including cell growth, metabolism, DNA repair, and important biological processes.[4]
As we age, the natural level of NAD+ in our body declines. Evidence demonstrates that NAD+ levels reduce by approximately 50% every 20 years.[5] This decline is linked to reduced energy, cellular function and signs of ageing. [6]
虽然NAD+可以推动通过饮食,[7] diet alone will not completely revive the inadequate levels. Elevate’s NAD+ boosting supplements are designed to support replenishing adequate NAD+ levels in the body.
Why not take NAD+ directly?
Direct NAD+ supplementation is inefficient because NAD+ molecules are too large to easily cross cell membranes. In contrast, NMN can easily enter cells and, once inside, is quickly converted to NAD+, making it a more effective way to boost NAD+ levels in the body.
- Bieganowski、P&Brenner、C2004年发现的烟酰胺核苷作为营养和保守的NRK基因设立一个Preiss处理程序的独立的路线NAD+在真菌和人',Cell,vol。 117,没有。 4,pp.495-502.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,pp.133-135.
- 小山雀、E2014年,'去,NAD+和老化',趋势在内分泌&新陈代谢,第一卷。 25,没有。 3,pp.219-226.
- 最近的研究成单核苷酸酰胺和老龄问题'2022年,天然产品组合,第一卷。 1,pp.1.
- 阴影,C2020年,'背后的科学NMN–一个稳定、可靠的NAD+活化剂和抗衰老分子'、综合医学,第一卷。 19,没有。 1.
- 最近的研究成单核苷酸酰胺和老龄问题'2022年,天然产品组合,第一卷。 1,pp.1.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,爱尔兰,第135.
纯NMN
NMN (Nicotinamide Mononucleotide) is a derivative of Vitamin B3 that directly boosts NAD+ production, a critical molecule for energy and cellular health.[1]
NMN is converted into NAD+ through a single enzymatic step within cells.[2]
In contrast, NR (Nicotinamide Riboside), another NAD+ booster, must first be converted into NMN through phosphorylation before becoming NAD+, making it a two-step process.
Research has also identified the Slc12a8 gene, which allows NMN to be directly absorbed into cells, making it a more efficient and stable option for increasing NAD+ levels.[3]
- Grozio、Mills,K.F、吉野,J,Bruzzone、S Sociali、G、Tokizane,K,&Imai,S.我2020年,'单核苷酸酰胺:勘探多样化的治疗应用的一个潜在的分子'、生物分子,第一卷。 10,没有。 3.
- 吉野,J,Mills,K.F,Yoon,M.J,&Imai,S.I.2011年,'单核苷酸酰胺,一个关键NAD+间,治疗的病理生理学的饮食和年龄分致糖尿病小鼠',细胞的新陈代谢,第一卷。 14,没有。 4,p. 528-536.
- Grozio、Mills,K.F、吉野,J,Bruzzone、S Sociali、G、Tokizane,K,&Imai,S.我2020年,'单核苷酸酰胺:勘探多样化的治疗应用的一个潜在的分子'、生物分子,第一卷。 10,没有。 3.
超级NMNH
Dihydronicotinamide Mononucleotide (NMNH) is a reduced form of NMN, which shows clinical promise in supporting a significant surge in NAD+ levels and a faster, longer lasting and more effective absorption than any other NAD+ booster on the global market.[1] In other words, Super NMNH is potentially more potent, thus more effective than Pure NMN.[2]
超级NMNH
20小时的稳定NAD+增加
The dynamics of Super NMNH (Reduced NMN) have been captivating scientists. Upon supplementation, Super NMNH rapidly elevated NAD+ levels within just 15 minutes at an unprecedented pace. What sets NMNH apart is its ability to sustain this elevation, with NAD+ levels remaining 2-fold for up to 20 hours. This contrasts sharply with the plateau observed with NMN.[3]
超级NMNH
多组织NAD+影响,5个器官
NMNH(减NMN)'s影响回荡跨越各种组织,超过了有效性NMN. 值得注意的是,NMNH触发的大量增加NAD水平内重要机构,如肝脏和肾脏,显示其潜力的全面蜂窝式的支持。 大脑肌肉、棕色的脂肪组织,并且心的所有关键中心的生物活动,也有经验的高NAD的水平,这是不可复制的NMN.[4]
超级NMNH
Clinical studies are currently being conducted on a larger scale, to validate Super NMNH’s efficacy against a wide range of health-related benefits including cardio protection, neuroprotection and liver protection.
Whilst Super NMNH does not have as much publicly available data as Pure NMN, the full extent of Super NMNH’s potential and additional clinical verification of these claims is being investigated through ongoing, extensive clinical studies on humans. To be notified of the latest peer-reviewed publications please click here to join our mailing list.
- Zapata-Pérez,R,Tammaro,A,Schomakers,B.V.,Scantlebery,A.M.L,丹尼斯,S,Elfrink,H.L、吉罗-Gerbetant,J,Cantó、C、*洛佩斯*奥纳多,C,McIntyre,R.L,van Weeghel、M*桑切斯-Ferrer,A&Houtkooper,R.H2021,'减单核苷酸酰胺是一个新的有力的NAD+前体在哺乳动物细胞和老鼠的实验Journal,vol. 35,没有。 4.
- Zapata-Pérez, R, Tammaro, A, Schomakers, B.V., Scantlebery, A. M. L, Denis, S, Elfrink, H. L, Giroud-Gerbetant, J, Cantó, C, López-Leonardo, C, McIntyre, R. L, van Weeghel, M, Sánchez-Ferrer, Á & Houtkooper, R. H 2021, ‘Reduced Nicotinamide Mononucleotide is a New Potent NAD+ Precursor in Mammalian Cells and Mice,’ The FASEB Journal, vol. 35, no. 4
- Zapata-Pérez,R,Tammaro,A,Schomakers,B.V.,Scantlebery,A.M.L,丹尼斯,S,Elfrink,H.L、吉罗-Gerbetant,J,Cantó、C、*洛佩斯*奥纳多,C,McIntyre,R.L,van Weeghel、M*桑切斯-Ferrer,A&Houtkooper,R.H2021,'减单核苷酸酰胺是一个新的有力的NAD+前体在哺乳动物细胞和老鼠的实验Journal,vol. 35,没有。 4.
- Zapata-Pérez,R,Tammaro,A,Schomakers,B.V.,Scantlebery,A.M.L,丹尼斯,S,Elfrink,H.L、吉罗-Gerbetant,J,Cantó、C、*洛佩斯*奥纳多,C,McIntyre,R.L,van Weeghel、M*桑切斯-Ferrer,A&Houtkooper,R.H2021,'减单核苷酸酰胺是一个新的有力的NAD+前体在哺乳动物细胞和老鼠的实验Journal,vol. 35,没有。 4.
纯NMN与超级NMNH
纯NMN和超NMNH都属于家NAD+提高前体,支持补充NAD+在体内的水平。[1]
While the two acronyms (NMN and NMNH) might appear similar and both belong to the house of NAD+ boosters, they refer to distinct compounds with varying roles and implications in the realm of health and biology.
To be notified of the latest peer-reviewed publications, please join our mailing list.
- 刘、Y、罗、C、Li、T、张,W,宗,Z,Liu X&邓,H(2021),'减单核苷酸酰胺(NMNH)有效提高NAD+和禁止显示个人的糖酵解,TCA循环,以及细胞的增长,Journal of蛋白质组学的研究,第一卷。 20中,没有。 5,pp.2596-2606.
Pure Resveratrol
Pure Resveratrol is a polyphenolic compound belonging to the polyphenols’ stilbenoids group.[1] Pure Resveratrol is naturally occurring and can be found in more than 70 plant species including red grapes, berries, peanuts and even red wine.[2]
Resveratrol was first recognised for its anti-cancer activity in 1997, and since then, it has paved the way for longevity supplements.[3] As a dietary supplement, studies demonstrate promising results that Pure Resveratrol may increase DNA repair and cell renewal.
- Cardiovascular health:
Pure Resveratrol supports cardiovascular health by improving endothelial function, reducing blood pressure, and lowering LDL cholesterol levels. These effects contribute to a lower risk of heart disease.[4] - Antioxidant Protection:
Pure Resveratrol acts as an antioxidant, helping to neutralize harmful free radicals that can damage cells and contribute to ageing processes.[5] - Anti-inflammation:
Chronic inflammation is associated with various age-related diseases. Pure Resveratrol has demonstrated anti-inflammatory properties that may help reduce inflammation and its negative effects on health.[6] - Neuroprotection:
Due to its multiple neuroprotection mechanisms, Pure Resveratrol can be used to treat neurological diseases, including Alzheimer’s Disease.[7]
- Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018,‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
- Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018, ‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
- Meng, X, Zhou, J, Zhao, C, Gan, R & Li, H 2020, ’Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review’, Foods, vol. 9, no. 3.
- Timmers, S, Konings, E, Bilet, L, Houtkooper, R, Weijer, T, Goossens, G, Hoeks, J, Krieken, S, Ryu, D, Kersten, S, Moonen-Kornips, E, Hesselink, M, Kunz, I, Schrauwen-Hingerling, V, Blaak, E, Auwerx, J & Schrauwen, P 2011, ‘Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans’, Cell Metabolism, vol. 14, no. 5, pp. 612-622.
- Sarubbo, F, Esteban, S, Miralles, A & Moranta, D 2018, ’Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging’, Curr Neuropharmacol, vol. 16, no. 2, pp. 126-136.
- Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018, ‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
- Rahman, M, Akter, R, Bhattacharya, T, Abdel-Daim, M, Alkahtani, S, Arafah, M, Al-Johani, N, Alhoshani, N, Alkeraishan, N, Alhenaky, A, Abd-Elkader, O, El-Seedi, H, Kaushik, D & Mittal, V 2020, ‘Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer’s Disease’, Frontiers, vol. 11.
Pure Apigenin
Pure Apigenin is a naturally occurring polyphenol from the flavonoid group, which is the largest class of polyphenols.[1] This bioactive compound is commonly found in various foods, especially in chamomile, parsley and celery. As a dietary supplement, Apigenin has show promise in effects on brain health and function.[2]
Research suggests that it supports brain health by promoting neurogenesis and protecting against oxidative stress.[3]
Additionally, Apigenin has calming properties, helping to reduce anxiety, promote relaxation and improve sleep quality, making it a popular natural option for enhancing mental and emotional wellbeing.[4]
- Brain Health:
Pure Apigenin has been found to have neuroprotective properties that may benefit brain health and function. Research has shown that Pure Apigenin can protect neurons from damage and reduce neuroinflammation.[5] - Stress reduction effects:
Cortisol is a hormone released in response to stress. High levels of cortisol over prolonged periods can lead to various health issues, including chronic stress. Pure Apigenin has been shown to modulate the release of cortisol, thereby helping to reduce stress levels.[6] - Relaxation & Sleep Quality:
Found in chamomile, Pure Apigenin contributes to the calming effects of chamomile tea. It binds to benzodiazepine receptors in the brain, which can help reduce anxiety and promote relaxation and sleep.[7] - Anti-Cancer Protection:
Pure Apigenin has shown promise in the prevention and treatment of various cancers. Studies have highlighted its ability to induce apoptosis (programmed cell death) and inhibit the proliferation of cancer cells.[8]
- Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
- Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
- Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
- Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
- Charriere, K, Schneider, V, Perrignon-Sommet, M, Lizard, G, Benani, A, Jacquin-Piques, A & Vejux, A 2024, ‘Exploring the Role of Apigenin in Neuroinflammation: insights and Implications’, Pub Med Central, vol. 25, no. 9.
- Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
- Gazola, A, Gosta, G, Castellanos, L, Ramos, F, Reginatto, F, de Lima, T, Schenkel, E 2015, ‘Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp’, Revista Brasileira de Farmacogenosia, vol. 25, no. 3.
- Cao, H. H., et al. “Apigenin induced apoptosis of human breast carcinoma MCF-7 cells through mitochondria- and caspase-3-dependent pathways.” Anticancer Drugs, vol. 22, no. 3, 2011, pp. 286-297
Pure Berberine
Pure Berberine is an alkaloid, a class of organic compounds known for their significant pharmacological effects on the human body.[1] It is primarily extracted from the roots, rhizomes, stems and bark of various plant species, including turmeric trees and barberry. Berberine has a long history of use in traditional medicine, particularly in Chinese medicine, where it has been valued for centuries for its therapeutic properties.[2]
In modern times, Berberine has gained prominence as a health supplement, supported by scientific research showing its benefits in weight management. It works by activating ken enzymes that regulate metabolism, improving insulin sensitivity and supporting healthy blood sugar levels.[3]
Additionally Berberine is being studied for its potential in improving heart health, reducing chloresterol and supporting gut health, making it a versatile supplement with a broad range of health benefits.[4]
- Blood sugar regulation:
Pure Berberine has been shown to improve insulin sensitivity and lower blood glucose levels. It activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance, which can help manage type 2 diabetes.[5] - Weight loss:
Studies suggest that Pure Berberine may help with weight loss by improving metabolic functions and reducing body fat. It also helps regulate hormones related to fat storage and appetite.[6] - Metabolism Support:
Pure Berberine can enhance fat burning and reduce the production of new fat cells, aiding in weight management.[7] - Cardiovascular Health:
Pure Berberine has been shown to improve cholesterol levels, which can contribute to better heart health.[8]
- Tillhon, M, Ortiz, L, Lombardi, P & Scovassi, A 2012, ‘Berberine: New perspectives for old remedies’, Biochemical Pharmacology, vol. 84, no. 10, pp. 1260-1267.
- Prajwala, B, Raghu, N, Gopennath, TS, Shanmukhappa, B, Karthikeyan, M, Ashok, G, Ranjith, M, Srinivasan, V & Basalingappa, K 2020, ‘Berberine And Its Pharmacology Potential: A Review’, European Journal of Biomedical And Pharmaceutical Science, vol. 7, no. 5, pp. 115-123.
- Ye, Y, Liu, X, Wu, N, Han, Y, Wang, J, Yu, Y & Chen, Q 2021, ‘Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials’, Frontiers in Pharmacology, vol. 12.
- Ye, Y, Liu, X, Wu, N, Han, Y, Wang, J, Yu, Y & Chen, Q 2021, ‘Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials’, Frontiers in Pharmacology, vol. 12.
- Yin, J, Xing, H & Ye, J 2008, ‘Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus’, Metabolism Clinical and Experimental, vol. 57, no. 5, pp. 712-717.
- Kong, W, Wei, J, Abidi, P, Lin, M, Inaba, S, Li, C, Wang, Y, Wang, Z, Si, S, Pan, H, Wang, S, Wu, J, Wang, Y, Li, Z, Liu, J & Jiang, J 2004, ’Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins’, Nature Medicine, vol. 10, pp. 1344-1351.
- Hu, X, Zhang, Y, Xue, Y, Zhang, Z & Wang, J 2018, ‘Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation’, American Journal of Translational Research, vol. 16, no. 9.
- Kong, W, Wei, J, Abidi, P, Lin, M, Inaba, S, Li, C, Wang, Y, Wang, Z, Si, S, Pan, H, Wang, S, Wu, J, Wang, Y, Li, Z, Liu, J & Jiang, J 2004, ’Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins’, Nature Medicine, vol. 10, pp. 1344-1351.
120+ years of scientific research on NAD+
1909
1929
Hans von Euler-Chelpin purified the NAD+ molecule, and discovered the initial insights into the chemical structure and characteristics of the co-factor essential for facilitating fermentation reactions. Von Euler-Chelpin and Harden were awarded the Nobel Prize for their pioneering research into fermentation.[2]
1936
1938
1948
1980
2004
2004
2011
2018
The World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time, added aging. [R] The classification of ‘aging as a disease’ paved the way for new research into novel therapeutics like NAD+ boosting supplementation, to delay or reverse age-related illnesses.
2019
Harvard Professor, Dr David Sinclair’s book ‘Lifespan’ is published, drawing much global attention on the benefits of boosting NAD+ levels to reduce age related disease. [R]
2021
2022
2023
2024
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,爱尔兰,第134.
- *冯*欧拉Chelpin,H1930年,'发酵的糖和酵酵素',诺贝尔演讲,瑞典的斯德哥尔摩。
- 吡啶,C.W&Warburg、O1936年,'Der wasserstoffübertragende的von Gärungsfermenten(翻译:氢转移的组成部分的发酵酵素)',黑体化学学学报,vol. 19,没有。 1,p. 79-88.
- Elvehjem,C.,et al.1974年,'隔离和识别的反黑人的舌头的因素,营养评论,vol. 32,no. 2,p. 48至50.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,爱尔兰,第134.
- Kornberg,1948年,'的参与无机磷酸中的可逆的酶的合成diphosphopyridine核苷酸',J.Chem Biol,第一卷。 176,没有。 3,第1475.
- 宇J2024年,第三代超级NAD+增压器、小册子。
- Bieganowski,P等人,2004年,'发现的烟酰胺核苷作为营养和保守的NRK基因设立一个Preiss处理程序的独立的路线NAD+在真菌和人',Cell,vol。 117,没有。 4,pp.495-502.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,爱尔兰,第135.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,爱尔兰,第135.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,第136.
- Sinclair,D&LaPlante,M2019年,使用寿命:为什么我们年龄和为什么我们没有,柯林斯出版社,爱尔兰都柏林,第136.
- Clinical Trials