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Science-Page---Our-Vision

The Challenge of a Short Healthspan

While advancements in science have steadily increased lifespan, they haven’t extended healthspan, which is the period of life spent in good health. Ageing remains the biggest risk factor for poor health, leading to chronic conditions that affect the quality of life in later years.

We envision a future where people maintain independence, enjoy their favourite activities and spend quality time with loved ones well into their life.

Though many face declining vitality, recent scientific breakthroughs offer hope for ageing with energy, flexibility, and a continued sense of wellbeing.

The Hallmarks of Ageing

As we age, the structure, function and processes within our cells change. The scientific community widely recognises several key factors, known as the “Hallmarks of Ageing”:

Genomic
Instability
Epigenetic

Alterations
Telomere

Attrition
Mitochondria
Dysfunction
Altered Intercellular
Communication
Stem Cell
Exhaustion
Cellular

Senescence
Deregulated
Nutrient Sensing
Loss of

Proteostasis
Disabled

Autophagy
Inflammaging
Microbiome

Dysbiosis

These hallmarks manifest externally through changes in skin elasticity, hair colour and pigmentation, and internally through issues like poor sleep, declining energy, altered autophagy, NAD+ levels and telomere structure.

Tailored Support for Biological Age

At Elevate BleuTM, we recognise that support needs differ at various stages of biological age. Our premium products are designed to provide targeted support based on your unique biological age or lifestyle factors. Our formulations support the ageing process in ways previous generations did not have access to, offering personalised solutions to enhance healthspan and improve overall wellbeing.

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Sciece-Page---Tailored

Traditionally, there are eleven body systems:

Nervous

System
Skeletal

System
Circulatory

System
Integumentary

System
Endocrine

System
Digestive

System
Respiratory

System
Immune

System
Muscular

System
Renal

System
Reproductive

System

In addition to these eleven systems, supporting your cellular health is the foundation for overall healthy ageing. By taking care of your cells, you support all eleven other body systems, promoting comprehensive wellbeing.

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NAD水平

  • NAD+ levels with precursor supplementation
  • 自然NAD水平与年龄

nad+

年龄

NAD+ and its significance explained

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of the body that plays a crucial role in energy production and maintaining cellular health.[1] 辅酶是经过科学证明，以提高活动的所有七个去.[2] When NAD+ levels are high, sirtuins become more active, supporting cellular function.[3]

NAD+ helps convert nutrients into energy and is responsible for critical cell functions, including cell growth, metabolism, DNA repair, and important biological processes.[4]

As we age, the natural level of NAD+ in our body declines. Evidence demonstrates that NAD+ levels reduce by approximately 50% every 20 years.[5] This decline is linked to reduced energy, cellular function and signs of ageing. [6]

虽然NAD+可以推动通过饮食，[7] diet alone will not completely revive the inadequate levels. Elevate’s NAD+ boosting supplements are designed to support replenishing adequate NAD+ levels in the body.

Why not take NAD+ directly?

Direct NAD+ supplementation is inefficient because NAD+ molecules are too large to easily cross cell membranes. In contrast, NMN can easily enter cells and, once inside, is quickly converted to NAD+, making it a more effective way to boost NAD+ levels in the body.

  1. Bieganowski、P&Brenner、C2004年发现的烟酰胺核苷作为营养和保守的NRK基因设立一个Preiss处理程序的独立的路线NAD+在真菌和人'，Cell,vol。 117，没有。 4,pp.495-502.
  2. Sinclair,D&LaPlante，M2019年，使用寿命：为什么我们年龄和为什么我们没有,柯林斯出版社，爱尔兰都柏林，pp.133-135.
  3. 小山雀、E2014年，'去，NAD+和老化'，趋势在内分泌&新陈代谢，第一卷。 25，没有。 3,pp.219-226.
  4. 最近的研究成单核苷酸酰胺和老龄问题'2022年，天然产品组合，第一卷。 1,pp.1.
  5. 阴影，C2020年，'背后的科学NMN–一个稳定、可靠的NAD+活化剂和抗衰老分子'、综合医学，第一卷。 19，没有。 1.
  6. 最近的研究成单核苷酸酰胺和老龄问题'2022年，天然产品组合，第一卷。 1,pp.1.
  7. Sinclair,D&LaPlante，M2019年，使用寿命：为什么我们年龄和为什么我们没有,柯林斯出版社，爱尔兰都柏林，爱尔兰，第135.

纯NMN

NMN (Nicotinamide Mononucleotide) is a derivative of Vitamin B3 that directly boosts NAD+ production, a critical molecule for energy and cellular health.[1]

NMN is converted into NAD+ through a single enzymatic step within cells.[2]

In contrast, NR (Nicotinamide Riboside), another NAD+ booster, must first be converted into NMN through phosphorylation before becoming NAD+, making it a two-step process.

Research has also identified the Slc12a8 gene, which allows NMN to be directly absorbed into cells, making it a more efficient and stable option for increasing NAD+ levels.[3] 

  1. Grozio、Mills,K.F、吉野，J，Bruzzone、S Sociali、G、Tokizane,K,&Imai,S.我2020年，'单核苷酸酰胺：勘探多样化的治疗应用的一个潜在的分子'、生物分子，第一卷。 10，没有。 3.
  2. 吉野,J,Mills,K.F,Yoon,M.J,&Imai,S.I.2011年，'单核苷酸酰胺，一个关键NAD+间，治疗的病理生理学的饮食和年龄分致糖尿病小鼠'，细胞的新陈代谢，第一卷。 14，没有。 4,p. 528-536.
  3. Grozio、Mills,K.F、吉野，J，Bruzzone、S Sociali、G、Tokizane,K,&Imai,S.我2020年，'单核苷酸酰胺：勘探多样化的治疗应用的一个潜在的分子'、生物分子，第一卷。 10，没有。 3.

超级NMNH

Dihydronicotinamide Mononucleotide (NMNH) is a reduced form of NMN, which shows clinical promise in supporting a significant surge in NAD+ levels and a faster, longer lasting and more effective absorption than any other NAD+ booster on the global market.[1] In other words, Super NMNH is potentially more potent, thus more effective than Pure NMN.[2]

01 /04

超级NMNH

20小时的稳定NAD+增加 

The dynamics of Super NMNH (Reduced NMN) have been captivating scientists. Upon supplementation, Super NMNH rapidly elevated NAD+ levels within just 15 minutes at an unprecedented pace. What sets NMNH apart is its ability to sustain this elevation, with NAD+ levels remaining 2-fold for up to 20 hours. This contrasts sharply with the plateau observed with NMN.[3]

02 /04

超级NMNH

多组织NAD+影响，5个器官

NMNH(减NMN)'s影响回荡跨越各种组织，超过了有效性NMN. 值得注意的是，NMNH触发的大量增加NAD水平内重要机构，如肝脏和肾脏，显示其潜力的全面蜂窝式的支持。 大脑肌肉、棕色的脂肪组织，并且心的所有关键中心的生物活动，也有经验的高NAD的水平，这是不可复制的NMN.[4]

03 /04

超级NMNH

Clinical studies are currently being conducted on a larger scale, to validate Super NMNH’s efficacy against a wide range of health-related benefits including cardio protection, neuroprotection and liver protection.

Whilst Super NMNH does not have as much publicly available data as Pure NMN, the full extent of Super NMNH’s potential and additional clinical verification of these claims is being investigated through ongoing, extensive clinical studies on humans. To be notified of the latest peer-reviewed publications please click here to join our mailing list.

SuperNMNH-Product-Photo
NMNH-Molecular-Structure
04 /04
  1. Zapata-Pérez,R，Tammaro，A，Schomakers,B.V.，Scantlebery,A.M.L，丹尼斯,S,Elfrink，H.L、吉罗-Gerbetant，J，Cantó、C、*洛佩斯*奥纳多，C，McIntyre,R.L,van Weeghel、M*桑切斯-Ferrer,A&Houtkooper,R.H2021,'减单核苷酸酰胺是一个新的有力的NAD+前体在哺乳动物细胞和老鼠的实验Journal,vol. 35，没有。 4.
  2. Zapata-Pérez, R, Tammaro, A, Schomakers, B.V., Scantlebery, A. M. L, Denis, S, Elfrink, H. L, Giroud-Gerbetant, J, Cantó, C, López-Leonardo, C, McIntyre, R. L, van Weeghel, M, Sánchez-Ferrer, Á & Houtkooper, R. H 2021, ‘Reduced Nicotinamide Mononucleotide is a New Potent NAD+ Precursor in Mammalian Cells and Mice,’ The FASEB Journal, vol. 35, no. 4
  3. Zapata-Pérez,R，Tammaro，A，Schomakers,B.V.，Scantlebery,A.M.L，丹尼斯,S,Elfrink，H.L、吉罗-Gerbetant，J，Cantó、C、*洛佩斯*奥纳多，C，McIntyre,R.L,van Weeghel、M*桑切斯-Ferrer,A&Houtkooper,R.H2021,'减单核苷酸酰胺是一个新的有力的NAD+前体在哺乳动物细胞和老鼠的实验Journal,vol. 35，没有。 4.
  4. Zapata-Pérez,R，Tammaro，A，Schomakers,B.V.，Scantlebery,A.M.L，丹尼斯,S,Elfrink，H.L、吉罗-Gerbetant，J，Cantó、C、*洛佩斯*奥纳多，C，McIntyre,R.L,van Weeghel、M*桑切斯-Ferrer,A&Houtkooper,R.H2021,'减单核苷酸酰胺是一个新的有力的NAD+前体在哺乳动物细胞和老鼠的实验Journal,vol. 35，没有。 4.

纯NMN与超级NMNH

纯NMN和超NMNH都属于家NAD+提高前体，支持补充NAD+在体内的水平。[1]

While the two acronyms (NMN and NMNH) might appear similar and both belong to the house of NAD+ boosters, they refer to distinct compounds with varying roles and implications in the realm of health and biology.

To be notified of the latest peer-reviewed publications, please join our mailing list.

  1. 刘、Y、罗、C、Li、T、张，W，宗，Z,Liu X&邓，H(2021),'减单核苷酸酰胺(NMNH)有效提高NAD+和禁止显示个人的糖酵解，TCA循环，以及细胞的增长，Journal of蛋白质组学的研究，第一卷。 20中，没有。 5,pp.2596-2606.

Pure Resveratrol

Pure Resveratrol is a polyphenolic compound belonging to the polyphenols’ stilbenoids group.[1] Pure Resveratrol is naturally occurring and can be found in more than 70 plant species including red grapes, berries, peanuts and even red wine.[2]

Resveratrol was first recognised for its anti-cancer activity in 1997, and since then, it has paved the way for longevity supplements.[3] As a dietary supplement, studies demonstrate promising results that Pure Resveratrol may increase DNA repair and cell renewal.

  • Cardiovascular health:
    Pure Resveratrol supports cardiovascular health by improving endothelial function, reducing blood pressure, and lowering LDL cholesterol levels. These effects contribute to a lower risk of heart disease.[4]
  • Antioxidant Protection:
    Pure Resveratrol acts as an antioxidant, helping to neutralize harmful free radicals that can damage cells and contribute to ageing processes.[5]
  • Anti-inflammation:
    Chronic inflammation is associated with various age-related diseases. Pure Resveratrol has demonstrated anti-inflammatory properties that may help reduce inflammation and its negative effects on health.[6]
  • Neuroprotection:
    Due to its multiple neuroprotection mechanisms, Pure Resveratrol can be used to treat neurological diseases, including Alzheimer’s Disease.[7]
  1. Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018,‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
  2. Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018, ‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
  3. Meng, X, Zhou, J, Zhao, C, Gan, R & Li, H 2020, ’Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review’, Foods, vol. 9, no. 3.
  4. Timmers, S, Konings, E, Bilet, L, Houtkooper, R, Weijer, T, Goossens, G, Hoeks, J, Krieken, S, Ryu, D, Kersten, S, Moonen-Kornips, E, Hesselink, M, Kunz, I, Schrauwen-Hingerling, V, Blaak, E, Auwerx, J & Schrauwen, P 2011, ‘Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans’, Cell Metabolism, vol. 14, no. 5, pp. 612-622.
  5. Sarubbo, F, Esteban, S, Miralles, A & Moranta, D 2018, ’Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging’, Curr Neuropharmacol, vol. 16, no. 2, pp. 126-136.
  6. Salehi, B, Mishra, A, Nigam, M, Sener, B, Kilic, M, Sharifi-Rad, M, Fokou, P, Martins, N & Sharifi-Rad, J 2018, ‘Resveratrol: A Double-Edged Sword in Health Benefits’, Biomedicines, vol. 6. no. 3, pp. 91.
  7. Rahman, M, Akter, R, Bhattacharya, T, Abdel-Daim, M, Alkahtani, S, Arafah, M, Al-Johani, N, Alhoshani, N, Alkeraishan, N, Alhenaky, A, Abd-Elkader, O, El-Seedi, H, Kaushik, D & Mittal, V 2020, ‘Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer’s Disease’, Frontiers, vol. 11. 

Pure Apigenin

Pure Apigenin is a naturally occurring polyphenol from the flavonoid group, which is the largest class of polyphenols.[1] This bioactive compound is commonly found in various foods, especially in chamomile, parsley and celery. As a dietary supplement, Apigenin has show promise in effects on brain health and function.[2]

Research suggests that it supports brain health by promoting neurogenesis and protecting against oxidative stress.[3]

Additionally, Apigenin has calming properties, helping to reduce anxiety, promote relaxation and improve sleep quality, making it a popular natural option for enhancing mental and emotional wellbeing.[4]

  • Brain Health:
    Pure Apigenin has been found to have neuroprotective properties that may benefit brain health and function. Research has shown that Pure Apigenin can protect neurons from damage and reduce neuroinflammation.[5]
  • Stress reduction effects:
    Cortisol is a hormone released in response to stress. High levels of cortisol over prolonged periods can lead to various health issues, including chronic stress. Pure Apigenin has been shown to modulate the release of cortisol, thereby helping to reduce stress levels.[6]
  • Relaxation & Sleep Quality:
    Found in chamomile, Pure Apigenin contributes to the calming effects of chamomile tea. It binds to benzodiazepine receptors in the brain, which can help reduce anxiety and promote relaxation and sleep.[7]
  • Anti-Cancer Protection:
    Pure Apigenin has shown promise in the prevention and treatment of various cancers. Studies have highlighted its ability to induce apoptosis (programmed cell death) and inhibit the proliferation of cancer cells.[8]
  1. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  2. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  3. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  4. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  5. Charriere, K, Schneider, V, Perrignon-Sommet, M, Lizard, G, Benani, A, Jacquin-Piques, A & Vejux, A 2024, ‘Exploring the Role of Apigenin in Neuroinflammation: insights and Implications’, Pub Med Central, vol. 25, no. 9.
  6. Salehi, B, Venditti, A, Sharifi-Rad, M, Kregiel, D, Sharifi-Rad, J, Durazzo, A, Lucarini, M, Sanrini, A, Souto, E, Novellino, E, Antolak, H, Azzini, E, Setzer, W & Martins, N 2019, ’The Therapeutic Potential of Apigenin’, International Journal of Molecular Sciences, vol. 20, no. 6.
  7. Gazola, A, Gosta, G, Castellanos, L, Ramos, F, Reginatto, F, de Lima, T, Schenkel, E 2015, ‘Involvement of GABAergic pathway in the sedative activity of apigenin, the main flavonoid from Passiflora quadrangularis pericarp’, Revista Brasileira de Farmacogenosia, vol. 25, no. 3.
  8. Cao, H. H., et al. “Apigenin induced apoptosis of human breast carcinoma MCF-7 cells through mitochondria- and caspase-3-dependent pathways.” Anticancer Drugs, vol. 22, no. 3, 2011, pp. 286-297

Pure Berberine

Pure Berberine is an alkaloid, a class of organic compounds known for their significant pharmacological effects on the human body.[1] It is primarily extracted from the roots, rhizomes, stems and bark of various plant species, including turmeric trees and barberry. Berberine has a long history of use in traditional medicine, particularly in Chinese medicine, where it has been valued for centuries for its therapeutic properties.[2]

In modern times, Berberine has gained prominence as a health supplement, supported by scientific research showing its benefits in weight management. It works by activating ken enzymes that regulate metabolism, improving insulin sensitivity and supporting healthy blood sugar levels.[3]

Additionally Berberine is being studied for its potential in improving heart health, reducing chloresterol and supporting gut health, making it a versatile supplement with a broad range of health benefits.[4]

  • Blood sugar regulation:
    Pure Berberine has been shown to improve insulin sensitivity and lower blood glucose levels. It activates AMP-activated protein kinase (AMPK), a key regulator of cellular energy balance, which can help manage type 2 diabetes.[5]
  • Weight loss:
    Studies suggest that Pure Berberine may help with weight loss by improving metabolic functions and reducing body fat. It also helps regulate hormones related to fat storage and appetite.[6]
  • Metabolism Support:
    Pure Berberine can enhance fat burning and reduce the production of new fat cells, aiding in weight management.[7]
  • Cardiovascular Health: 
    Pure Berberine has been shown to improve cholesterol levels, which can contribute to better heart health.[8]
  1. Tillhon, M, Ortiz, L, Lombardi, P & Scovassi, A 2012, ‘Berberine: New perspectives for old remedies’, Biochemical Pharmacology, vol. 84, no. 10, pp. 1260-1267.
  2. Prajwala, B, Raghu, N, Gopennath, TS, Shanmukhappa, B, Karthikeyan, M, Ashok, G, Ranjith, M, Srinivasan, V & Basalingappa, K 2020, ‘Berberine And Its Pharmacology Potential: A Review’, European Journal of Biomedical And Pharmaceutical Science, vol. 7, no. 5, pp. 115-123.
  3. Ye, Y, Liu, X, Wu, N, Han, Y, Wang, J, Yu, Y & Chen, Q 2021, ‘Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials’, Frontiers in Pharmacology, vol. 12.
  4. Ye, Y, Liu, X, Wu, N, Han, Y, Wang, J, Yu, Y & Chen, Q 2021, ‘Efficacy and Safety of Berberine Alone for Several Metabolic Disorders: A Systematic Review and Meta-Analysis of Randomized Clinical Trials’, Frontiers in Pharmacology, vol. 12.
  5. Yin, J, Xing, H & Ye, J 2008, ‘Efficacy of Berberine in Patients with Type 2 Diabetes Mellitus’, Metabolism Clinical and Experimental, vol. 57, no. 5, pp. 712-717.
  6. Kong, W, Wei, J, Abidi, P, Lin, M, Inaba, S, Li, C, Wang, Y, Wang, Z, Si, S, Pan, H, Wang, S, Wu, J, Wang, Y, Li, Z, Liu, J & Jiang, J 2004, ’Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins’, Nature Medicine, vol. 10, pp. 1344-1351.
  7. Hu, X, Zhang, Y, Xue, Y, Zhang, Z & Wang, J 2018, ‘Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation’, American Journal of Translational Research, vol. 16, no. 9. 
  8. Kong, W, Wei, J, Abidi, P, Lin, M, Inaba, S, Li, C, Wang, Y, Wang, Z, Si, S, Pan, H, Wang, S, Wu, J, Wang, Y, Li, Z, Liu, J & Jiang, J 2004, ’Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins’, Nature Medicine, vol. 10, pp. 1344-1351.

120+ years of scientific research on NAD+

1909

NAD+发现了英国的生物化学家阿瑟*强化和威廉*约翰年轻，而他们正在调查含酒精的发酵酵母。 硬化和青年命名的化合物cozymase，现在被称为NAD+.[1]
1909

1929

Hans von Euler-Chelpin purified the NAD+ molecule, and discovered the initial insights into the chemical structure and characteristics of the co-factor essential for facilitating fermentation reactions. Von Euler-Chelpin and Harden were awarded the Nobel Prize for their pioneering research into fermentation.[2]

1929

1936

通过他的调查发酵反应，奥托*海因里希*Warburg发现，NAD是至关重要的特定类型的化学反应称为氢化物的转移。 氢化反应中发挥重要的角色细胞的新陈代谢和各种其他化学过程，重要的维持生活。[3]
1936

1938

康拉德Elvehjem确认NAD+能够治愈黑舌病的狗在犬相当于糙皮病、[4] 这是一个系统性疾病而引起维生素B3(烟)缺乏。[5]
1938

1948

阿瑟Kornberg隔离所有的部件所需NAD+-产生的反应，从酵母细胞和组装他们在一个实验性配置，以说明他们的作用NAD+生产。 Kornberg的实验标记的最初示范细胞化学反应负责将前体分子单核苷酸酰胺(NMN)成NAD+.[6]
1948

1980

奥地利格拉茨大学教授乔治*Birkmayer，从部药用化学，第一次应用的减少形成的NAD+疾病的治疗。[7]
1980

2004

查尔斯*伦纳揭示了这一形式的维生素B3，称为酰胺核苷(R)是一个至关重要的前体(基本上是一个构建模块)的NAD+. 伦纳识NR被检测出少量的食物，诸如牛奶，并发现，它可能延长预期寿命。[8] 这是一个转折点，在那里营养成了一种手段的提高NAD+级和NR是销售由吨每个月。[9]
2004

2004

虽然研究NMN,Dr.David Sinclair确定是检测到的少量食物，如绿色蔬菜和草莓。 沿着与同龄人，Dr.Sinclair检测出体内，NR转换成NMN，然后转换成NAD+.[10]
2004

2011

Shin博士一郎Imai表明，NMN能治疗症状的2型糖尿病在成熟的老鼠，通过恢复NAD水平。[11] 其他的实验表明，NMN可以减少的线粒体疾病、神经变性和肾损伤。[12]
2011

2018

The World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time, added aging. [R] The classification of ‘aging as a disease’ paved the way for new research into novel therapeutics like NAD+ boosting supplementation, to delay or reverse age-related illnesses.

2018

2019

Harvard Professor, Dr David Sinclair’s book ‘Lifespan’ is published, drawing much global attention on the benefits of boosting NAD+ levels to reduce age related disease. [R]

2019

2021

Due to public interest, and growing evidence showing potential for therapeutic applications, the volume of human clinical trials on NAD+ boosting supplements increases significantly.[3]
2021

2022

The largest clinical trial on NMN to date was published showing NAD+ level increasing by 38% after 60 days of supplementation.[13]
2022

2023

The safety and efficacy of NMN to boost NAD+ continued and was validated by various global institutions [13] Additionally, Nicotinamide Dihydronucleotide (NMNH) a reduced form of NMN, showed great clinical promise in studies in mice [14]
2023

2024

NMN continues to be studied globally for its myriad of benefits [13] whilst NMNH is in human clinical trials [14]
2024
  1. Sinclair,D&LaPlante，M2019年，使用寿命：为什么我们年龄和为什么我们没有,柯林斯出版社，爱尔兰都柏林，爱尔兰，第134.
  2. *冯*欧拉Chelpin，H1930年，'发酵的糖和酵酵素'，诺贝尔演讲，瑞典的斯德哥尔摩。
  3. 吡啶，C.W&Warburg、O1936年，'Der wasserstoffübertragende的von Gärungsfermenten(翻译：氢转移的组成部分的发酵酵素)'，黑体化学学学报，vol. 19，没有。 1,p. 79-88.
  4. Elvehjem,C.,et al.1974年，'隔离和识别的反黑人的舌头的因素，营养评论，vol. 32,no. 2,p. 48至50.
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  13. Clinical Trials